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PureNano_logo_miniContinuous Crystallizer

As leading pharmaceutical companies continue to explore the benefits of continuous manufacturing and bottom-up nanoparticle creation, Microfluidics' PureNano Continuous Crystallizer is being used to create stabile inhalable formulations, improve the bioavailability of antibiotics and target delivery of novel cancer treatments, among other possibilities. PureNano is a platform technology with several innovative applications:

  • Continuous crystallization - read a new educational white paper on pharmaceutical crystallization pdf-tiny
  • Efficient nanoencapsulation
  • Chemical reactions
  • Process intensification

Proven Processing Results

nano50PureNano (then known as MRT) has been named a Nano50 Award winner due to its unique capabilities to produce superior particle size distributions efficiently for a number of APIs:

Active Pharmaceutical Ingredient
PureNano Crystallization
1 pass (nm)
Beaker Crystallization (nm)
Top-down Particle Size Reduction
25 passes (nm)
Norfloxacin 180 3,000 x 1,000,000 428
Oxcarbazepine 767 5,000 x 20,000 1,200
Loratadine 90-332  

 

Azithromycin

Crystallization achieved a z-average of 82 nm
(ranging as small as 54 nm) with narrow distribuion.

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